Cabtreo

clindamycin - adapalene - benzoyl peroxide

How Does This Medication Work?

This combination product contains 3 medications: clindamycin, adapalene, and benzoyl peroxide. Together, these medications belong to the group of medications called acne therapy. It is used by people 12 years of age and older, to treat acne.

Clindamycin is an antibiotic. Benzoyl peroxide and clindamycin work by killing bacteria associated with acne. Adapalene works by unplugging blocked oil glands in the skin. Benzoyl peroxide also reduces inflammation on the skin. This medication usually starts to work within several weeks. Additional improvement will occur as you continue to use the gel.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How Should I Use This Medication?

Clindamycin - adapalene - benzoyl peroxide should be applied to the affected skin areas once daily. Before applying the medication, wash your skin, rinse with warm water, and gently pat dry. Use the pump to put a pea-sized amount of this medication on your fingertip. Dot the medication on your chin, cheeks, nose and forehead. A pea-sized amount of gel should be enough to cover the entire face. Rub the gel in gently, avoiding contact with eyes, nostrils, mouth, and sensitive skin. If contact does occur, rinse with plenty of cool tap water. Wash your hands before and after using this medication.

Do not apply the gel to cuts, broken skin, eczema, or sunburned skin.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to use this medication exactly as prescribed by your doctor. If you miss a dose, apply it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not use a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children. Discard any medication that remains in the pump after 10 weeks.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What Form(S) Does This Medication Come In?

Each gram of white to off-white, opaque, smooth, water-based gel contains 1.2% clindamycin phosphate (12 mg), 0.15% adapalene (1.5 mg), and 3.1% benzoyl peroxide (31 mg). Nonmedicinal ingredients: carbomer homopolymer Type C (Carbomer 980), potassium hydroxide, propylene glycol, and purified water.

Who Should Not Take This Medication?

Do not take this medication if you:

  • are allergic to clindamycin, adapalene, benzoyl peroxide, or any ingredients of the medication

  • have or have had ulcerative colitis, Crohn’s disease, or colitis caused by antibiotic use

  • are or are planning to become pregnant

What Side Effects Are Possible With This Medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • burning or stinging at the application site

  • dry skin

  • itchiness

  • peeling skin

  • rash

  • redness and swelling

  • scaling

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • blisters

  • lightening or darkening skin patches

  • sunburn

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)

  • symptoms of bowel inflammation (e.g., severe or persistent diarrhea, abdominal pain, nausea and vomiting)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are There Any Other Precautions Or Warnings For This Medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Colitis: When applied to the skin, clindamycin is absorbed into the bloodstream and can cause colitis (inflammation of the colon). Contact your doctor immediately if you experience abdominal pain, cramps or bloating, severe watery diarrhea that may be bloody, or nausea and vomiting.

**Other skin treatments: **You should not use other acne medications or treatments applied to the skin while you are using this medication, unless recommended by your doctor. Also, avoid using other products that may irritate the skin (e.g., medicated or abrasive soaps, cosmetics that have strong skin-drying effects, and products with high concentrations of alcohol, astringents, spices, or lime). Avoid waxing, chemical hair removal, chemical peels, dermabrasion, or laser treatments on skin that is treated with this medication. It is recommended that you use cosmetics that do not clog your pores while using this medication.

This medication may bleach hair and coloured fabric. Be careful when applying this medication around the hairline and use white pillowcases and sheets.

Proper use: This medication should only be applied to the skin. Do not apply on eyes, lips, corners of the nose, mucous membranes (e.g., inside the mouth or nose), broken skin, cuts, sunburned skin, or open wounds. If the gel is accidently applied to these areas, rinse thoroughly with water.

Some people using this medication have reported temporary worsening of their acne during the first few weeks of use. This occurs as the skin adjusts to the effects of the medication and should disappear as the medication takes effect. If acne worsens or doesn’t begin to clear, contact your doctor.

Skin irritation: Skin redness, dryness, scaling, burning, or itchiness may occur, especially during the first 4 weeks of using this medication. These effects are usually mild and lessen with continued treatment. If you experience severe skin irritation or if skin irritation that continues or worsens, contact your doctor. Your doctor may recommend a moisturizer, change your dose, or change how often you use the medication.

Sun sensitivity: This medication can increase the sensitivity of your skin to the sun. Avoid prolonged exposure to sunlight, and do not use sunlamps or tanning beds while you are using this medication. When you are exposed to the sun, be sure to use an adequate sunscreen and wear protective clothing (e.g., a hat).

Pregnancy: This medication should not be used during pregnancy. If you can become pregnant, you should use effective birth control while you are using this medication. If you become pregnant while using this medication, stop using it and contact your doctor immediately.

Breast-feeding: It is not known if clindamycin - adapalene - benzoyl peroxide passes into breast milk. If this medication is applied to the chest area, an infant may come into contact with the medication or ingest it from the parent's skin, affecting the child.

If you are breast-feeding and taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children under 12 years of age.

What Other Drugs Could Interact With This Medication?

**For a full list of interactions, use the Drug Interaction Checker **available on the Drugs.com website.

If you are taking other medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,

  • change one of the medications to another,

  • change how you are taking one or both of the medications, or

  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2025. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Cabtreo